Randy Pausch, a computer science professor at Carnegie Mellon University, died early Friday at his home in Virginia.
The 47-year-old became famous after the "last lecture" he delivered in September 2007 became an Internet sensation, watched by millions online.
He had been diagnosed with incurable pancreatic cancer one year earlier -- and given just three to six months to live.
"We can't change the cards we're dealt, just how we play the hand," the computer science professor says at the beginning of his lecture. "If I don't seem as morose or depressed as you think I should be, sorry to disappoint you."
The husband and father of three young children goes on to deliver a phenomenally uplifting message, speaking about achieving your dreams. At one point he even does pushups to demonstrate the strength he still had in his cancer-ridden body.
He later said the message was meant as a "message in a bottle" to his kids Logan, Dylan and Chloe.
The momentum of the YouTube video was carried over to a book project that Pausch embarked on with Jeffrey Zaslow, a columnist at the Wall Street Journal.
The book "The Last Lecture" is essentially a series of lectures that Pausch delivered by cell phone to Zaslow as he rode his bicycle to stay fit.
It climbed to the top of the best-seller list when it was published in April and remains there still.
Pausch was a professor of computer science and human-computer interaction and design, and was considered by many to be a pioneer in virtual reality research. He also co-founded the Carnegie Mellon Entertainment Technology Center -- a facility designed to bring artists and engineers together.
He was known at Carnegie Mellon -- where he also studied and received a Ph.D. -- for his energetic and exuberant style as a teacher and mentor.
Watch the last lecture through the link on the right hand side of this page.
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